Formulation and evaluation of doxepin hydrochloride by fast dissolving buccal film

Tricyclic antidepressants, as doxepin hydrochloride (DH), may also have analgesic neighborhood effect due to its biochemical mechanism of action. This is commonly performed via drug be administers directly into the blood flow Buccal mucosa through using fast dissolving movie system. The main aim study was formulate and evaluate Doxepin by buccal film. film were prepared solvent casting method different polymers (HPMC E15, PVA, HEC). FTIR test conducted this there no interaction between polymers. Then evaluated for weight uniformity, thickness folding endurance, disintegration study, content invitro release. uniformity ranged from 47.00 55.33mg, 0.17 0.25nm, endurance 344 355mm 84 98% 42.0 54.3. F9 formulation showed highest release i.e., 99.96% within 4 minutes. IR spectra stable properties hcl mixture used revealed absence selected polymer, stability studies per ich guideline result indicated that stable.